A study led by researchers at Karolinska Institutet analyzed national health registry data from Sweden, Denmark, and Norway involving more than 280,000 patients with type 2 diabetes treated with SGLT2 inhibitors. [1]
Patients with type 2 diabetes who have high blood glucose levels, low body weight, or a history of ketoacidosis are at increased risk of developing ketoacidosis when treated with SGLT2 inhibitors. [2] Infection was identified as the most common triggering or co-occurring event in cases of ketoacidosis among patients taking SGLT2 inhibitors. [3] The study showed that the risk of ketoacidosis remains elevated throughout the entire course of treatment, not just during the initial stages. [4]
Artificial intelligence can now analyze millions of chemical compounds and identify therapeutic molecules, reducing drug discovery times that historically required years and billions of dollars. [5] Cardiovascular diseases remain the leading cause of death worldwide, with over 20.5 million deaths per year, according to the World Heart Federation. [6] The author argues that the pharmaceutical industry is solving the wrong problem by focusing on diagnosis and treatment rather than prevention. [7]
The author proposes that the next step is to build systems capable of continuous patient accompaniment using wearables, remote monitoring, and AI to intervene when habits are forming. [8]Un estudio dirigido por investigadores del Karolinska Institutet analizó datos de registros de salud nacionales de Suecia, Dinamarca y Noruega que involucran a más de 280,000 pacientes con diabetes tipo 2 tratados con inhibidores de SGLT2. [1]
Los pacientes con diabetes tipo 2 que tienen niveles altos de glucosa en sangre, bajo peso corporal o antecedentes de cetoacidosis tienen un mayor riesgo de desarrollar cetoacidosis cuando se tratan con inhibidores de SGLT2. [2] La infección se identificó como el evento desencadenante o concomitante más común en los casos de cetoacidosis entre pacientes que toman inhibidores de SGLT2. [3] El estudio mostró que el riesgo de cetoacidosis permanece elevado durante todo el curso del tratamiento, no solo en las etapas iniciales. [4]
La inteligencia artificial ahora puede analizar millones de compuestos químicos e identificar moléculas terapéuticas, reduciendo los tiempos de descubrimiento de fármacos que históricamente requerían años y miles de millones de dólares. [5] Las enfermedades cardiovasculares siguen siendo la principal causa de muerte en todo el mundo, con más de 20.5 millones de muertes al año, según la World Heart Federation. [6] El autor argumenta que la industria farmacéutica está resolviendo el problema equivocado al centrarse en el diagnóstico y el tratamiento en lugar de la prevención. [7]
El autor propone que el siguiente paso es construir sistemas capaces de acompañamiento continuo del paciente utilizando dispositivos portátiles, monitoreo remoto y AI para intervenir cuando se están formando hábitos. [8]
Proof8 sources · 2 publishers
What this stands on
A study led by researchers at Karolinska Institutet analyzed national health registry data from Sweden, Denmark, and Norway involving more than 280,000 patients with type 2 diabetes treated with SGLT2 inhibitors. · Medical Xpress
Patients with type 2 diabetes who have high blood glucose levels, low body weight, or a history of ketoacidosis are at increased risk of developing ketoacidosis when treated with SGLT2 inhibitors. · Medical Xpress
Infection was identified as the most common triggering or co-occurring event in cases of ketoacidosis among patients taking SGLT2 inhibitors. · Medical Xpress
The study showed that the risk of ketoacidosis remains elevated throughout the entire course of treatment, not just during the initial stages. · Medical Xpress
Artificial intelligence can now analyze millions of chemical compounds and identify therapeutic molecules, reducing drug discovery times that historically required years and billions of dollars. · El Financiero
Cardiovascular diseases remain the leading cause of death worldwide, with over 20.5 million deaths per year, according to the World Heart Federation. · El Financiero
The author argues that the pharmaceutical industry is solving the wrong problem by focusing on diagnosis and treatment rather than prevention. · El Financiero
The author proposes that the next step is to build systems capable of continuous patient accompaniment using wearables, remote monitoring, and AI to intervene when habits are forming. · El Financiero
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